The Human Tissue Act 2004 and the associated Code of Practice for Archaeological Human Remains govern how such remains are held and managed, and the museum follows these guidelines in its stewardship of the collection.

The 2018 analysis was conducted with the appropriate institutional approvals and with the deliberate minimization of destructive sampling — the two-millimeter drilling into the skull, extracting just a few milligrams of bone powder, was chosen specifically to minimize damage to the specimen while obtaining sufficient material for analysis.

The museum has made the Cheddar Man materials and associated research accessible to the scientific community.

The genome data generated by the 2018 analysis has been deposited in publicly accessible databases, allowing other researchers to work with the genetic data without needing to destructively sample the specimen again.