The 2018 Science paper that published his genome has been cited by subsequent studies of ancient American populations.

The methodological approaches developed in that study have been refined and applied elsewhere.

The finding that the earliest well-preserved American genomes are most closely related to modern Native American populations has been replicated in additional studies, and the general conclusion — that the morphological distinctiveness of early American skulls reflects variation within a single founding population rather than the existence of a separate founding group — has been consistently supported.

The Spirit Cave Man’s contribution to science is not finished.