One of the most important is whether additional human remains exist in the cave system — either in Hoyo Negro itself or in other chambers connected to it.

A single individual can tell us much, but a population — even a small one, even a fragmentary one — can tell us things that one person cannot.

If multiple individuals from the same general period were preserved in the same cave system, the genetic diversity among them could constrain models of early American population structure in ways that the Naia haplogroup alone cannot.

The broader cave system connected to Hoyo Negro is vast, and only portions of it have been systematically explored at the level of detail needed to identify and document paleontological or archaeological material.