The haplogroups found in Native American populations trace their origin to northeastern Asian populations.

The founding Native American haplogroups — labeled A, B, C, D, and X, with various subcategories including A2 and B2 — are found almost exclusively in Indigenous peoples of the Americas and in specific northeastern Asian populations that are most closely related to the founding Beringian population.

The presence of haplogroup A2 and B2 sequences in the Paisley coprolites indicated that the individuals who produced those specimens had maternal ancestry traceable to the same founding lineages as modern Native American peoples.

This finding was significant because it established a biological connection between the ancient coprolite producers and the Indigenous people of the Americas — not a connection to European populations, not a connection to African populations, not a connection to Asian populations in general, but specifically to the founding lineages of Native America.