During this period, they were isolated from the Asian populations to the west and from the Americas to the south and east.

The genetic drift that occurs in small, isolated populations — the random changes in allele frequencies that happen when populations are small and isolated for extended periods — would have produced the distinctive genetic profile that we see in Native American populations today.

The mixing between Ancient North Eurasian and East Asian-ancestry populations, which produced the founding population of the Americas, would have occurred before this standstill period — before the population entered Beringia and became isolated.

MA-1 represents the Ancient North Eurasian side of that mixing, from before the Beringian isolation.