Other researchers in the field of ancient genomics immediately began assessing the implications of the ANS discovery for their own work: models of population history that had not accounted for the ANS now needed to be updated.

Datasets that had been collected without reference to the ANS could now be re-analyzed with the ANS genome as a reference point.

The implications spread outward from the specific findings of the paper in ways that continue to develop.

The identification of the ANS as a distinct lineage provided a new reference point for understanding the genetic diversity of the Pleistocene; studies of other ancient genomes from the period could now ask whether ANS-related ancestry was present, and in what proportions, in populations across northern Eurasia.

The connection between the ANS, the Kolyma1 individual, and Native American ancestry provided a more detailed picture of the population history of the Beringian gateway to the Americas than had previously been available.