The ancient DNA evidence from multiple sites across the Americas has broadly confirmed this picture while adding nuance and complexity.

The Anzick Child, a 12,600-year-old individual from Montana whose genome was published in 2014, belongs to the lineage that gave rise to most modern Native Americans.

The ancient individuals from Hoyo Negro in the Yucatan Peninsula, dated to roughly 12,000 years ago, also connect to the same founding lineage despite having cranial morphology that was initially interpreted as different from most modern Native Americans.

The Spirit Cave mummy from Nevada, roughly 10,600 years old, similarly falls within the founding lineage that connects to modern Native Americans.