What if the key to understanding Alzheimer’s disease cannot be in the brain, but in the mouth?
For decades, we have been told that Alzheimer’s is a mysterious, incurable state, but what if the hidden factor, often overlooked, could contribute to his onset?
Recent pioneering studies suggest that the cause of Alzheimer’s disease can be associated not only with aging or genetics, but may also include an infection that we are all familiar with: gingle disease.
This interesting option caused a wave of scientific research and questioned everything we thought we knew about Alzheimer’s disease.
Could the health of your teeth and gums really keep the key to prevent or even reverse this devastating illness? Let’s dive into shocking findings that change the traditional understanding of Alzheimer’s feet up.
Alzheimer’s is the main cause of dementia in the UK, according to V // 5. Although the exact cause remains unclear, it is assumed that several factors contribute to its development, including age, untreated depression, family history of disease and lifestyle selection associated with cardiovascular conditions.
In recent years, however, a growing part of research suggests that Alzheimer’s disease may not be not only a neurodegenerative disease, but may also be caused by infection.
The 2019 study suggests that gum disease could play a role in the development of Alzheimer. Research led by microbiologist Jan Potempa of the University of Louisville found that bacteria *porfyromonas gingivalis *, pathogen responsible for chronic gum disease, in the brains of individuals who died of Alzheimer’s disease.
In previous experiment on mice carried out by Cortexyme, Inc. Scientists found that the infection of rodents *p. Gingivalis* led to increased production of beta-amyloid-cellar protein commonly associated with Alzheimer’s disease-in their brains.
“Infectious agents were suspected of contributing to Alzheimer’s disease earlier, but evidence of direct thing was unconvincing,” Dr. Stephen Dominy, co -founder of Cortexyme.
The team also examined Gingipains, toxic enzymes produced by *p. Gingivalis*and found that higher levels of these enzymes were associated with the presence of two other proteins associated with Alzheimer’s disease: Tau and Ubikvitin.
Interestingly, they also discovered these gingipains in the brains of deceased individuals who have never been diagnosed with Alzheimer’s disease. This raises the question of whether these individuals would eventually develop this disease or whether poor oral hygiene contributed to the condition as soon as Alzheimer’s chocoed.
“OUR Identification of Gingipain Antigens in the Brains of Individuals with Alzheimer’s and Those with Alzheimer’s-Related Brain Changes But No Dementia diagnosis Suggests That Brain Infection With Afterset or Conseque of Late-Stage Disease.
In addition, the study of the mouse showed a reduction in the production of amyloid beta and neuroinflamation after treatment with a compound developed by cortexym called COR388.
However, it remains uncertain whether this treatment would have the same effect on humans.
“While drugs aimed at toxic bacteria proteins have been shown to have only been operating only in mice, lack of new dementia treatment over 15 years is essential to explore all possible approaches to solving Alzheimer and similar diseases,” said David Reynolds.
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In conclusion, a growing set of research connecting gum disease with Alzheimer’s disease suggests that the health of the oral cavity can play a more important role in the development of the disease than previously thought. While the exact mechanisms are still being examined, the presence of * Porphyromonas Gingivalis * and its toxic enzymes in the brain of Alzheimer’s patients raises important questions about the potential of early detection and new therapeutic strategies.
Although much more research is needed to confirm these findings, research on bacteria, such as the COR388, offers hope in finding effective therapies. When we continue to look for a solution for Alzheimer’s disease, understanding the connection between the health of the oral cavity and the function of the brain could lead to pioneering progress in prevention and treatment.