This geographic pattern is consistent with some models but not others.

Ancient genomes from Uruguay have been analyzed and also show Native American ancestry.

The relationships between these ancient individuals and the populations of the Lagoa Santa region have been characterized, contributing to an emerging picture of the genetic landscape of early South America.

Some of these individuals show evidence of the same kind of ancestry as the Lagoa Santa people; others show different patterns.

Ancient material from Panama — geographically positioned at the narrowest point of the land connection between North and South America and therefore at a critical juncture in any model of South American settlement — has also been analyzed.