Migration events can be inferred.

Patterns of admixture — the mixing of previously separated populations — can be detected in the genomic signatures of modern and ancient individuals.

The Anzick genome was the first ancient American genome precise and complete enough to make these kinds of analyses feasible at the continental scale.

It established a baseline — a genomic snapshot of the Americas at approximately 12,600 years ago — against which subsequent ancient and modern genomes could be compared.

In the decade since its publication, the number of ancient American genomes available for such comparisons has grown from one to more than a hundred, and the picture they collectively paint is coming into increasingly sharp focus.