The most plausible corridor runs along the Caribbean coast of northwestern Colombia and then inland through the lower slopes of the Andes, eventually ascending the Eastern Cordillera to reach the Altiplano.

This route would have involved crossing multiple ecological zones — tropical lowlands, subtropical montane forest, cool highland environments — and adapting to the physiological demands of increasing altitude.

Alternatively, movement could have occurred through the western slope of the Andes, down through the Cauca Valley that separates the Cordillera Occidental from the Cordillera Central, and then across to the Eastern Cordillera.

Or through the lowland llanos to the east of the mountains, with ascending access through the eastern passes of the Cordillera.

The specific routes taken by the populations who brought Central American ancestry to the Altiplano remain unknown.