Each new ancient genome contributes either additional support for the existing model or new constraints that force revision.

Genomes from sites in Siberia and northeastern Asia have been particularly important for understanding the pre-divergence history of the founding population — the period before the people who would become the first Americans separated from their Asian relatives and began accumulating the distinct genetic character of Native Americans.

These ancient genomes from the Asian side of the Bering region have helped researchers characterize the specific Asian populations that contributed to the founding of the Americas, refining the model of where the founding population came from and when it separated from its Asian relatives.

The analysis of modern Native American genomes with increasing depth and breadth has also contributed to the refinement of the early American population models.